49ers @ Giants (+6.5, -110)
I can bash the Giants no problem. The issue is, however, is that their offensive line is just bad. They play at the Chicago Bears in Week 2 while the 49er's play at the New York Jets. The 49er's strength is still on the defensive line, and they will still be able to manhandle this Giants o-line in Week 3. The 49er's left for their Week 2 game on Saturday, play a game Sunday, and then travel to West Virginia for the next week of practice. They then play at the New York Giants the following week. Case in point: the 49er's will be in an unfamiliar bubble with no friends, family, or ability to go out. San Francisco will struggle Week 2 with so many injuries, and the Giants +6.5 is the only way I can look now. The 49er's will be a better play later, after a close game with Jets. If you want the Giants, grab them right now.